Which statement about Zolpidem is TRUE?

Zolpidem is a medication primarily used as a sedative for the short-term treatment of insomnia. The statement regarding the reversibility of an overdose by Flumazenil is true because Flumazenil is a benzodiazepine antagonist that can reverse the central nervous system effects of benzodiazepines and related compounds, including zolpidem. Zolpidem, while not a traditional benzodiazepine, acts on the same class of receptors, specifically GABA-A receptors, and can thus have its sedative effects antagonized by Flumazenil.

Other statements suggest different characteristics of Zolpidem. The characterization of cognitive impairment linked to BZ2 receptor activity does not reflect the primary actions of Zolpidem, as it is more selective for the BZ1 subtype associated with sleep rather than cognition. While tolerance can develop with long-term use, Zolpidem does not have a high abuse potential compared to other sedative-hypnotics, making claims about high tolerance and abuse liability less accurate. Furthermore, Zolpidem is not primarily indicated for anxiety disorders; it is used mainly to treat insomnia.