Which of the following is true about the pharmacokinetics of benzodiazepines?

The statement regarding the pharmacokinetics of benzodiazepines that is true states that diazepam has a longer half-life than midazolam. Diazepam is known for its extended half-life, which can range from 20 to 50 hours due to its active metabolites. This extended duration of action makes diazepam particularly useful for conditions that require prolonged sedation or anxiety relief.

In contrast, midazolam is a short-acting benzodiazepine, with a half-life typically around 1 to 4 hours. Its shorter half-life is advantageous in procedural sedation where rapid recovery is desired. This comparison between the half-lives of diazepam and midazolam highlights the differences in their pharmacological profiles and clinical applications.

Other statements about oxazepam being metabolized to inactive compounds, the excretion routes of all benzodiazepines, and the onset of action of temazepam might not accurately reflect the pharmacokinetic properties of these drugs or the variability among different benzodiazepines.