Which of the following drugs can cause disulfiram-like effects?

The correct answer is associated with cefotetan, which is known to produce disulfiram-like effects when alcohol is consumed. Disulfiram, commonly used to support the treatment of chronic alcoholism, works by inhibiting the enzyme aldehyde dehydrogenase. This leads to an accumulation of acetaldehyde when alcohol is ingested, causing various unpleasant effects such as flushing, palpitations, and nausea.

Cefotetan, a cephalosporin antibiotic, contains a methylthiotetrazole side chain that can similarly inhibit aldehyde dehydrogenase, resulting in similar adverse reactions if alcohol is consumed during treatment. This interaction is important to monitor due to the potential for severe reactions.

The other choices—ibuprofen, diphenhydramine, and acetaminophen—do not exhibit this disulfiram-like interaction with alcohol. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) primarily used for pain management and does not have an alcoholic reaction. Diphenhydramine is an antihistamine used for allergies and motion sickness and does not induce disulfiram-like effects. Acetaminophen is a pain reliever and fever reducer that, while it poses risks of liver toxicity with alcohol