Which neurotransmitters are primarily affected by SSRIs?

SSRIs, or selective serotonin reuptake inhibitors, are specifically designed to increase the levels of serotonin in the brain. They achieve this by inhibiting the reuptake of serotonin into the presynaptic neuron, thus allowing more serotonin to be available in the synaptic cleft for receptor binding. This leads to enhanced serotonergic neurotransmission, which is crucial for mood regulation and is why SSRIs are commonly prescribed for depression and anxiety disorders.

While norepinephrine can also be influenced in some cases by certain types of antidepressants, the primary action of SSRIs centers around serotonin. This selective mechanism makes them particularly effective in treating conditions associated with low serotonin levels, distinguishing them from other classes of antidepressants that may target different neurotransmitters more broadly. Understanding the core action of SSRIs provides insight into their clinical use and the biochemical basis of mood disorders.