Which drug is commonly used for general tonic-clonic seizures?

Valproic acid is a broad-spectrum anticonvulsant that is particularly effective for treating various seizure types, including general tonic-clonic seizures. It works by enhancing the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) and inhibiting excitatory neurotransmitter activity, which helps stabilize neuronal membranes and reduce seizure frequency.

While other options may have their uses in managing seizures, they do not typically serve as first-line therapies for general tonic-clonic seizures. Ethosuximide is specifically effective for absence seizures, making it less suitable for this type of seizure. Gabapentin, primarily used for neuropathic pain and partial seizures, is not the mainstay for general tonic-clonic seizures. Carbamazepine is more commonly indicated for partial seizures and also has efficacy for secondary generalized tonic-clonic seizures, but valproic acid provides a broader coverage and is often preferred for generalized forms.

Thus, valproic acid is recognized for its versatility and effectiveness in treating general tonic-clonic seizures, which is why it stands out as the appropriate choice in this context.