Which drug class does bupropion belong to?

Bupropion is classified as a norepinephrine and dopamine reuptake inhibitor (NDRI). This mechanism of action primarily involves the inhibition of the reuptake of norepinephrine and dopamine neurotransmitters in the brain, which helps to enhance mood and alleviate depressive symptoms. Bupropion is commonly used as an antidepressant and is also effective for smoking cessation.

Understanding why bupropion does not belong to the other classes is essential. Selective serotonin reuptake inhibitors (SSRIs) focus mainly on serotonin reuptake inhibition, addressing mood disorders with a different mechanism. Tricyclic antidepressants (TCAs) have a broader spectrum of action, affecting multiple neurotransmitter systems, but their side effect profile is often less favorable. Monoamine oxidase inhibitors (MAOIs) primarily inhibit the enzyme that breaks down neurotransmitters, leading to increased levels of norepinephrine, serotonin, and dopamine, but they require dietary restrictions and have significant interactions with other medications.

This distinct action of bupropion as a norepinephrine and dopamine reuptake inhibitor is what makes it a unique choice in the treatment of depression and other conditions, differentiating it from the other mentioned classes.