Which benzodiazepine has a stronger anxiolytic effect, BZ2 or BZ1?

The correct choice for the benzodiazepine with a stronger anxiolytic effect is BZ2. This is due to the distinct mechanisms between the two subtypes of benzodiazepine receptors in the brain, namely BZ1 and BZ2. BZ2 receptors are primarily associated with the anxiolytic effects of benzodiazepines, as activation of these receptors enhances the inhibitory neurotransmitter GABA's action, which plays a crucial role in reducing anxiety.

In contrast, BZ1 receptors are more closely tied to sedative and hypnotic effects rather than anxiolytic properties. While BZ1 may also modulate some aspects of anxiety, its primary role relates to promoting sleep and sedation rather than directly alleviating anxiety symptoms.

Thus, the evidence indicates that BZ2 has a more pronounced effect on anxiety reduction compared to BZ1, making it the appropriate choice for stronger anxiolytic effects among benzodiazepines.