Which adverse effect is commonly associated with Lamotrigine?

Lamotrigine is an anticonvulsant medication primarily used to treat epilepsy and bipolar disorder. A significant adverse effect associated with lamotrigine is Stevens-Johnson syndrome (SJS), a serious and potentially life-threatening skin reaction. SJS is characterized by flu-like symptoms followed by a painful rash that spreads and blisters, which can lead to peeling of the skin and mucous membrane involvement.

The risk of developing Stevens-Johnson syndrome with lamotrigine is particularly heightened in certain situations, such as when the drug is initiated at too high of a dose or when it is combined with other medications that can also increase this risk. The careful titration of lamotrigine dosage is essential to minimize this risk, and patients are often advised to report any early signs of rash immediately.

In contrast, nephrotoxicity, hepatic failure, and cognitive impairment are not commonly associated with lamotrigine use. While some medications might lead to kidney damage, liver failure, or cognitive decline, these are not primary concerns with lamotrigine, making Stevens-Johnson syndrome the notable adverse effect in this context.