What is the primary mechanism of action for Atomoxetine?

Atomoxetine primarily functions as a selective norepinephrine reuptake inhibitor (NRI). This mechanism of action involves preventing the reabsorption of norepinephrine in the synaptic cleft, thereby increasing its availability and action at adrenergic receptors in the brain. By enhancing norepinephrine neurotransmission, Atomoxetine helps to improve attention and reduce hyperactivity and impulsivity, making it effective in treating attention deficit hyperactivity disorder (ADHD).

The significance of norepinephrine in this context lies in its role in modulating arousal and cognitive functions, which are often impaired in individuals with ADHD. Atomoxetine’s selectivity for norepinephrine reuptake means it primarily influences this neurotransmitter system without significantly affecting dopamine, which is distinct from many other ADHD medications that act as stimulants and influence dopaminergic pathways. This selectivity contributes to Atomoxetine's profile as a non-stimulant treatment option for ADHD.