What is a characteristic of benzodiazepine withdrawal?

Benzodiazepine withdrawal is characterized by the presence of seizures, which is a significant and clinical safety concern related to the cessation of these medications. This happens because benzodiazepines enhance the inhibitory effects of GABA, a neurotransmitter that produces calming effects in the brain. Over time, with prolonged use, the brain becomes reliant on the drug to maintain this balance. Upon withdrawal, this dependency may lead to a hyperexcitable state as GABAergic activity diminishes, resulting in the risk of seizures.

In addition to seizures, other withdrawal symptoms can include anxiety, insomnia, tremors, and even psychotic symptoms in severe cases. Therefore, recognizing seizures as a hallmark of withdrawal is essential for clinicians and patients alike in order to manage the withdrawal process safely. Other options suggested in the question do not align as well with the well-documented symptoms of benzodiazepine withdrawal; for example, gradual improvement in symptoms is unlikely, and prolonged sedation would not typically reference withdrawal but rather the effects during active use of the drug. Enhanced mood stability is also not characteristic of withdrawal, as mood disturbances often occur instead.